２０２４年
◆Uno K, Teoh SH, Sekiguchi K, Suzuki-Kemuriyama N, Ohta T, Miyajima K
Granulomatous Myocarditis Caused by Candida Spp Infection in a Spontaneously Diabetic Torii Rat
Med. Arch., 2024; 78(2): 177-179
◆Saigo Y, Uno K, Ishigure T, Odake T, Ohta T
Pathophysiological Features of Rat Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
In Vivo, in press
◆Ishigure T, Sasase T, Tohma M, UNO K, Toriniwa Y, Saito T, Saigo Y, Edamura K, Miyajima K, Ohta T
Western diet-induced nonalcoholic fatty liver disease mice mimic the key transcriptomic signatures observed in humans
Physiol. Res., in press
◆Maekawa M, Maekawa T, Sasase T, Wakashima T, Uemura A, Ohta T, Yamada T
Renal transcriptome analysis of uninephrectomized db/db mice identified a mechanism for the transition to severe diabetic nephropathy
Exp. Anim., 2024; 73(1): 29-40
◆Tanaka Y, Takagi R, Mitou S, Shimmura M, Hasegawa T, Someya S, Shinohara M, Kageyama Y, Sasase T, Ohta T, Muramatsu S, Kakehashi A, Kaburaki T
Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats
Biol. Pharm. Bull., 2024 ;47(3):713-722
博士学位論文
Studies on the utility of nonalcoholic fatty liver disease (NAFLD) animal models using genome-wide gene expression analysis.
Tatsuya Ishigure, 2024
２０２３年
◆Sano R, Ryu K, Sasase T, Shinozaki Y, Teoh SH, Yamaguchi A, Uno K, Maekawa T, Ohta T, Miyajima K
Effects of salt supplementation in uninephrectomized KK-Ay mice: Examining the potential of a diabetic kidney disease model
J. Toxicol. Sci., 2023; Vol. 48, No.11: 597-606
◆Sasase T, Fatchiyah F, Ohta T
Retinal ganglion cell death is slower in the guinea pig optic nerve transection model than in the rat
JSMARTech., 2023; 04, 01
◆Ishigure T, Sasase T, Tohma M, Uno K, Toriniwa Y, Saito T, Saigo Y, Edamura K, Miyajima K, Ohta T
Choline-deficient diet-induced NAFLD animal model recaptures core human pathophysiology with similar gene co-expression networks
In Vivo., 2023; 37:1517-1531
◆Saigo Y, Sasase T, Tohma M, Uno K, Shinozaki Y, Maekawa T, Sano R, Miyajima K, Ohta T
High-cholesterol diet in combination with hydroxypropyl-β-cyclodextrin induced NASH-like disorders in the liver of rats
Physiol. Res., 2023; 72:371-382
◆Masuko R, Yamada T, Sukegawa S, Ohta T, Yamazaki M, Inoue H, Fujii T, Iwaisaki H
Identification of TGFβ signaling pathway showing heat stress-responsive activation associated with heat stress tolerance for growth rate in small intestine of finishing pig
The Journal of Animal Genetics., 2023; 51:49-55
◆Shinozaki Y, Fukui K, Maekawa M, Toyoda K, Yoshiuchi H, Inagaki K, Uno K, Miyajima K, Ohta T
Unilateral nephrectomized SHR/NDmcr-cp rat shows a progressive decline of glomerular filtration with tubular interstitial lesions
Physiol. Res., 2023; 72:209-220
その他
◆太田毅
Unmet Medical Needsを意識したモデル動物のキャラクタリゼーション
関西実験動物研究会会報、令和5年11月 41号、8-12
２０２２年
◆Masuko R, Sukegawa S, Ohta T, Yamada T, Yamazaki M, Inoue H, Fujii T, Okamoto S, Iwasaki H
Identidfication of PPARGC1A-regulated oxidative phosphorylation pathway showing heat stress-responsive activation associated with low heat stress tolerance for growth rate in skeletal muscle tissue of finishing pig
The Journal of Animal Genetics., 2022; 50:49-54
◆Hasegawa T, BS, Takagi R, Tanaka Y, MD, PhD, Ohta T, PhD, Shinohara M, PhD, Kageyama Y, Sasase T, PhD, Muramatsu S, MD, PhD, Kaburaki T, MD, PhD, and Kakehashi A, MD, PhD
Differences in the Effects of Pentobarbital Anesthetic and Combination of Medetomidine Hydrochloride, Midazolam, and Butorphanol Tartrate Anesthetic on Electroretinogram in Spontaneously Diabetic Torii Fatty Rats
Biomedicine Hub., 2022; 7(3):106-114
◆Maekawa T, Sasase T, Shinohara M, Ohta T
Morphological analysis of the retina in salt-loaded KK-Ay mice, obese and type 2 diabetic model
JSMARTech., 2022; 3(1):11-15
◆Saigo Y, Sasase T, Uno K, Shinozaki Y, Maekawa T, Sano R, Toriniwa Y, Miyajima K, Ohta T
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats
J. Pharmacol. Toxicol. Methods, 2022; 116:107190
◆Maekawa M, Maekawa T, Sasase T, Takagi K, Takeuchi S, Kitamoto M, Nakagawa T, Toyoda K, Konishi N, Ohta T, Yamada T
Pathophysiological analysis of uninephrectomized db/db mice as a model of severe diabetic kidney disease
Physiol. Res., 2022; 71(2):209-217.
◆Sasase T, Fatchiyah F, Ohta T
Transient receptor potential vanilloid (TRPV) channels: Basal properties and physiological potential.
Gen. Physiol. Biophy., 2022;41(3):165-190.
◆Maekawa T, Sugimoto M, Kume S, Ohta T
Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats
J. Vet. Med. Sci., 2022; 84(3):330-337.
◆Shinozaki Y, Katayama Y, Yamaguchi F, Suzuki T, Watanabe K, Uno K, Tsutsui T, Sugimoto M, Shinohara M, Miyajima K, Ohta T
Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease
Clin. Exp. Pharmacol. Physiol., 2022; 49:492-500.
◆Kobayashi K, Sasase T, Maekawa T, Shinozaki Y, Sano R, Yamada T, Ohta T
Immune disorders and sex differences in spontaneously diabetic torri rats, type 2 diabetic model
Physiol. Res., 2022; 71(1):113-123
◆Maekawa T, Sasase T, Shinohara M, Kume S, Ohta T
Brain abnormalities in spontaneously diabetic Torii-Leprfa(SDT fatty) rats
AIP Conference Proceedings 2513, 020005(2022)
２０２１年
◆Teoh SH, Miyajima K, Shinozaki Y, Shinohara M, Ohata K, Briand F, Morimoto R, Nakamura Y, Uno K, Kemuriyama N, Nakae D, Ohta T, Maekawa T
Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus
J. Toxicol. Sci., 2021; 46(12):589-599.
◆Okunomiya A, Horie A, Tani H, Sato Y, Takamatsu S, Brown JB, Sugimoto M, Hamanishi J, Kondoh E, Matsumura N, Mandai M
Figla promotes secondary follicle growth in mature mice.
Sci. Rep., 2021; 11:9842.
◆Fatchiyah F, Setiawan B, Sasase T, Ohta T
The amelioration of T2DM rat femoral bone achieved by anti-osteoporosis of caprine CSN1S2 protein through bone morphogenetic protein signaling pathway
Acta Biochim. Pol., 2021; 68(2):265-275.
◆Maekawa T, Nakamura S, Miyajima K, Uno K, Yamaguchi A, Mandai K, Gotoh T, Shinohara M, Shinozaki Y, Sasase T, Fatchiyah F, Ohta T
Ocular changes -cataract and retinal lesion- in Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
JSMARTech., 2021; 2(2):81-86.
◆Sasase T, Ito M, Ishii Y, Ohta T
Bilateral midbrain transection induced hyperphagia accelerates the development of diabetes in Spontaneously Diabetic Torii (SDT) rats
JSMARTech., 2021; 2(2):69-74.
◆Wada M, Yukawa K, Ogasawara H, Suzawa K, Maekawa T, Yamamoto Y, Ohta T, Lee E, Miki T
GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice
iScience., 2021; 24:102260.
◆Kurimoto T, Tamai I, Nakagawa T, Miyai A, Yamamoto Y, Kosugi Y, Deai K, Hata T, Ohta T, Matsushita M, Yamada T
JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits significant anti-inflammatory effect while maintaining bone mineral density in mice
Eur. J. Pharmacol., 2021; 895:173880.
◆Sano R, Ishi Y, Yamanaka M, Yasui Y, Kemmochi Y, Kuroki F, Sugimoto M, Fukuda S, Sasase T, Miyajima K, Nakae D, Ohta T
Glomerular hyperfiltration with hyperglycemia in the Spontaneously Diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model
Physiol. Res., 2021; 70:45-54.
◆Tadaki H, Ogawa N, Yamanaka M, Motohashi Y, Sasase T, Kawai T, Toriniwa Y, Fukuda S, Ogawa N, Harada K, Ohta T, Yamada T
JTP-109192, a novel G-protein coupled receptor 119 agonist, prevents atherosclerosis by improving hypercholesterolemia in congenic spontaneously hyperlipidaemic mice.
Clin. Exp. Pharmacol. Physiol., 2021; 48:381-388.
◆Kobayashi K, Sasase T, Ishii Y, Katsuda Y, Miyajima K, Yamada T, Ohta T
The sphingosine-1-phosphate receptor modulator, FTY720, prevents the incidence of diabetes in Spontaneously Diabetic Torii rats.
Clin. Exp. Pharmacol. Physiol., 2021; 48(6):869-876.
◆山本修平・稲葉信博・前野孝之・平尾直啓・山中沙織・篠崎雄一・太田毅
ケージ内環境変化に伴うラットの居住性評価方法の確立
実験動物技術, 2021; 56(1):7-14
２０２０年
◆Fatchiyah F, Rohmah RN, Tripsila LF, Ohta T, Meidinna HN
The Caprine casein-alpha-S2 protein modulates the molecular mechanism of insulin signal transduction in Type2 diabetes rat.
Acta Biochim. Pol., 2020; 67:401-408.
◆Ishitani H, Ikeda S, Egashira K, Sugimoto M, Kume S, Minami N, Ohta T
Embryonic MTHFR contributes to blastocyst development.
J. Assist. Reprod. Genet., 2020; 37:1807-1814.
◆Sano R, Shinozaki Y, Ohta T
Sodium glucose co-transporters: functional properties and pharmaceutical potential.
J. Diabetes Investig., 2020; 11:770-782.
Top Cited Article 2020-2021 受賞！
◆Nakane Y, Kemmochi Y, Ogawa N, Sasase T, Ohta T, Higami Y, Fukai F
Hyperglycemia contributes to a development of leydig cell hyperplasia in male Spontaneously Diabetic Torii rats.
J. Toxicol. Pathol., 2020; 33:121-129.
◆Iida A, Matsushita M, Ohta T, Yamada T
Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats.
J. Vet. Med. Sci., 2020; 82(3):379-386.
◆Murai Y, Sasase T, Tadaki H, Heitaku S, Imagawa N, Yamada T, Ohta T
Analysis of haemodynamics and angiogenic response to ischaemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats.
Clin. Exp. Pharmacol Physiol., 2020; 47:583-590.
２０１９年
◆Yamada T, Nagata H, Ikenori D, Taniguchi Y, Ohta T, Sugiyama T, Homma K, Kaneko Y, Iwaisaki H
Molecular assessment of genetic diversity in the Japanese population of the Japanese crested ibis.
Ornitholog. Sci., in press.
◆Maekawa M, Tadaki H, Tomimoto D, Okuma C, Sano R, Ishii Y, Katsuda Y, Yoshiuchi H, Kakefuda R, Ohta T, Sasae T
A novel TNF-α converting enzyme (TACE) selective inhibitor JTP-96193 prevents insulin resistance in KK-Ay Type 2 diabetic mice and diabetic peripheral neuropathy in type 1 diabetic mice.
Biol. Pharm. Bull., 2019; 42(11):1906-1912.
◆Tadaki H, Sasase T, Fukuda S, Toriniwa Y, Harada K, Ohta T, Yamada T
Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats.
Clin. Exp. Pharmacol. Physiol., 2019; 46:910-919.
◆Tanaka Y, Takagi R, Ohta T, Sasase T, Kobayashi M, Toyoda F, Shimmura M, Kinoshita N, Takano H, Kakehashi A
Pathological features of diabetic retinopathy in Spontaneously Diabetic Torii fatty rats.
J. Diabetes Res., 2019; 8724818.
◆Fatchiyah F, Nurmasari DA, Masruro N, Rohmah RN, Triprisila LF, Mulyati M, Yamada T, Ohta T
Level of mRNA insulin gene and blood glucose STZ-induced diabetic rat are improved by glucomannan of amorphophallus muelleri blume from East Java forest Indonesia.
J. Trop. Life Sci., 2019; 9(2):163-169.
◆鳥庭靖文・斉藤友幸・谷合枝里子・石井幸仁・美谷島克宏・前川竜也・篠原雅巳・山田宜永・太田毅
Quick Fat 食給餌が肥満2型糖尿病モデル SDT fatty ラットの肝臓に及ぼす影響
北信越畜産学会報 2019; 118:1-8.
◆斉藤友幸・鳥庭靖文・石井幸仁・美谷島克宏・前川竜也・植村淳弘・篠原雅巳・山田宜永・太田毅
コレステロール負荷 Zucker fatty ラット肝臓の病態生理学的変化
北信越畜産学会報 2019; 118:9-15.
◆前川麻梨子・唯木洋暢・勝田佳朋・篠原雅巳・美谷島克宏・山田宜永・太田毅
肥満2型糖尿病モデル動物 SDT fatty ラットの腸管病理解析
北信越畜産学会報 2019; 118:17-24.
～２０１８年
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