生体機構学分野京都大学大学院農学研究科応用生物科学専攻

Laboratory of Animal Physiology and Functional Anatomy

 

研究業績 

-各業績からのリンクには、学外からの場合、閲覧に制限がある場合があります。-
2018
Toriniwa Y, Muramatsu M, Ishii Y, Riya E, Miyajima K, Ohshida S, Kitatani K, Takekoshi S, Matsui T, Kume S, Yamada T, Ohta T (2018)
Pathophysiological characteristics of non-alcoholic steatohepatitis-like changes in cholesterol-loaded type 2 diabetic rats.
Physiol Res.
67(4):601-612.

Murata R, Sugimoto M, Ikeda S, Nakatsuji Y, Kume S (2018)
Effects of supplemental water-soluble β-carotene on IgA induction in the intestine and mammary glands of lactating mice.
Trace Nutrients Research 35:52-57.

池田俊太郎
(2018)
栄養素による初期胚のエピジェネティック制御 ―DOHaDの視点から―

日本胚移植学雑誌
40(3):123-131.

Maekawa T, Ohta T, Kume S (2018)
Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats, a novel type 2 diabetic model.
J. Vet. Med. Sci.
80(9):1385-1391.

Sakimura K, Maekawa T, Kume S, Ohta T (2018)
Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 diabetes mellitus, shows blunted circadian rhythms and melatonin secretion.
Int. J. Endocrinol.
2018:9065690.

Ishida M
, Nishijima Y, Ikeda S, Yoshitani K, Obata A, Sugie Y, Aoki Y, Yamaji T, Fujita M, Nakatsuji Y, Kume S (2018)
Effects of supplemental β-carotene on colostral immunoglobulin and plasma β-carotene and immunoglobulin in Japanese Black cows.
Anim. Sci. J. 89(8):1102-1106.

Sakimura K, Maekawa T, Sasagawa K, Ishii Y, Kume S, Ohta T (2018)

Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of Type 2 Diabetes Mellitus.

Clin. Exp. Pharmacol. Physiol. 45(9):927-933.

Toriniwa Y, Saito T, Miyajima K, Ishii Y, Uno K, Maekawa T, Matsui T, Kume S, Yamada T, Ohta T (2018)
Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model.
J. Vet. Med. Sci. 80(6):878-885.

Suyatno, Kitamura Y, Ikeda S, Minami N, Yamada M, Imai H (2018)
Long-term culture of undifferentiated spermatogonia isolated from immature and adult bovine testes.
Mol. Reprod. Dev. 85(3):236-249.


Ikeda S, Sugimoto M, Kume S (2018)
Lipofection of siRNA into bovine 8-16-cell stage embryos using zona removal and the well-of-the-well culture system.
J. Reprod. Dev. 64(2):199-202.


Ikeda S, Sugimoto M, Kume S (2018)
The RPMI-1640 vitamin mixture promotes bovine blastocyst development in vitro and downregulates gene expression of TXNIP with epigenetic modification of associated histones.
Journal of DOHaD 9(1):87-94.


2018
Maekawa T, Tadaki H, Sasase T, Motohashi Y, Miyajima K, Ohta T, Kume S (2017)
Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model.
J. Pharmacol. Toxicol. Methods. 88(Pt 2):160-166.

石田真穂
西島嘉隆谷口紗耶北村勇人池田俊太郎・葭谷健一・濱野貴史・谷浩・藤田雅彦・村上賢司・小草啓輔・佐藤健史・杉本実紀久米新一 (2017)
黒毛和種繁殖牛の分娩直後の血漿中免疫グロブリン濃度の変動要因と分娩後の血漿中免疫グロブリン濃度に及ぼす乾燥ニンジン給与の影響
日本畜産学会報 88:439-444.

葭谷健一・谷口紗耶・濱野貴史・谷浩・藤田雅彦・村上賢司・池田俊太郎・小草啓輔・佐藤健史・久米新一 (2017)
黒毛和種繁殖牛の分娩前後の血漿成分に及ぼす乾燥ニンジン給与の影響
肉用牛研究会報
103:38-42.


Ikeda S, Kawahara-Miki R, Iwata H, Sugimoto M, Kume S (2017.6)
Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions.
Sci. Rep. 7(1):3800.

阪上真優池田俊太郎杉本実紀・小草啓輔・佐藤健史・久米新一 (2017)
泌乳マウスの小腸と乳腺における免疫グロブリンA産生に及ぼす乾燥ニンジンの影響
関西畜産学会報 174:10-16.


Nishijima Y, Taniguchi S, Ikeda S, Yoshitani K, Hamano T, Tani H, Fujita M, Murakami K, Kogusa K, Sato K, Sugimoto M, Kume S (2017.4)
Effects of β-carotene-enriched dry carrots on β-carotene status and colostral immunoglobulin in β-carotene-deficient Japanese Black cows.
Anim. Sci. J. 88(4):653-658.

久米新一 (2017)
β−カロテンを活用した黒毛和種子牛の疾病予防と腸管免疫改善
栄養生理研究会報 61(1):1-8.


2018
橋本知明・松山奈央・杉本実紀・池田俊太郎・久米新一
(2016)
離乳仔マウスと泌乳マウスのIgA産生に及ぼすペプチド亜鉛の影響
微量栄養素研究 33:59-62.


Okuma C, Ohta T, Ito M, Tadaki H, Oda T, Kume S, Nishiu J, Kakutani M (2016.2)

Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats.
J. Pharmacol. Sci. 130(2):136-138.


Taniguchi S
, Wang M, Ikeda S, Yoshioka H, Nagase H, Kitamura S, Itoyama E, Murakami H, Sugimoto M, Kume S
(2016.4)
Relationships between immunoglobulin M and immunoglobulin G or A in colostrum of Japanese Black multiparous cows.

Anim. Sci. J.
87(4):536-540.


池田俊太郎 (2016.2)
家畜初期胚におけるニュートリエピジェネティクス
-One-carbon metabolism の初期胚発生における役割-
栄養生理研究会報 60(1):1-11.


2018
泉谷紗也佳・杉本実紀・池田俊太郎・久米新一 (2015)
離乳後マウスの小腸におけるIgA 産生に及ぼすビタミンC の影響
微量栄養素研究 32:63-66.


谷口紗耶・王蒙東・池田俊太郎・吉岡秀貢長瀬祐士北村祥子
糸山恵理奈村上弘明小草啓輔佐藤健史・杉本実紀・久米新一 (2015)
黒毛和種繁殖牛の初乳中免疫グロブリン含量に及ぼす乾燥ニンジン給与の影響

日本畜産学会報 86(4):473-479.


酒井豪太・前田佳祐・杉本実紀・池田俊太郎・木村一雅・久米新一 (2015)
泌乳マウスの乳腺における免疫グロブリンA産生に及ぼすガラクトオリゴ糖の影響

日本畜産学会報 86(3):319-324.


Kudo M, Ikeda S, Sugimoto M, Kume S (2015.12)
Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos.
J. Nutr. Biochem. 26(12):1664-1669.


Ishii Y, Motohashi Y, Muramatsu M, Katsuda Y, Miyajima K, Sasase T, Yamada T, Matsui T, Kume S, Ohta T (2015.8)
Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions.

World J. Gastroenterol.
21:9067-9078.


Okuma C, Ohta T, Tadaki H, Hamada H, Oda T, Taniuchi H, Yamanaka K, Ishii Y, Ohe Y, Yata S, Nishiu J, Aratsu Y, Oshida S, Kume S, Kakutani M (2015.7)
JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity.

Eur. J. Pharmacol.
758:72-81.


Okuma C, Ohta T, Tadaki H, Ishigure T, Sakata S, Taniuchi H, Sano R, Hamada H, Kume S, Nishiu J, Kakutani M (2015.7)
JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis.
J. Pharmacol. Sci. 128:150-157.


Katsuda Y, Sasase T, Tadaki H, Mera Y, Motohashi Y, Kemmochi Y, Toyoda K, Kakimoto K, Kume S, Ohta T (2015.5)
Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin.
Exp. Anim. 64:161-169.


Wang M, Ikeda S, Yoshioka H, Nagase H, Kitamura S, Itoyama E, Murakami H, Sugimoto M, Kume S (2015.7)
Relationships between immunoglobulin and fat-soluble vitamins in colostrum of Japanese Black multiparous cows.

Anim. Sci. J.
86(7):673-678.


2018
Wang M, Sugimoto M, Ikeda S, Mukai K, Kume S (2014)
Effects of supplemental β-cryptoxanthin on IgA-secreting cells in the intestine and mammary glands of lactating mice.

Trace Nutrient Research
31:21-26.


宿院享・杉本実紀・池田俊太郎・久米新一 (2014.11)
泌乳マウスの飲水量と腎機能に及ぼす塩化カリウム給与水準の影響

日本畜産学会報 85:503-507.

Kamano S, Ikeda S, Sugimoto M, Kume S (2014.8)
The effects of calcitonin on the development of and Ca2+ levels in heat-shocked bovine preimplantation embryos in vitro.

J.Reprod.Dev.
60:317-323.


Nagayama T, Sugimoto M, Ikeda S, Kume S (2014.4)
Effects of astaxanthin-enriched yeast on mucosal IgA induction in the jejunum and ileum of weanling mice.

Anim.Sci.J.
85:449-453.


久米新一 (2014.2)
黒毛和種子牛の栄養管理と疾病予防
関西畜産学会報
 171:9-15.


Nishida K, Sugimoto M, Ikeda S, Kume S (2014.1)
Effects of supplemental β-carotene on mucosal IgA induction in jejunum and ileum of mice after weaning.

Brit.J.Nutr.
111:247-253.

Ikeda S, Yamada M (2014.2)
Midkine and cytoplasmic maturation of mammalian oocytes in the context of ovarian follicle physiology.

Brit.J.Pharmacol.
171:827-836.

2018
安松谷恵子・笠井浩司・山中健吾・坂瀬充洋・西野治・赤池勝・万所幸喜久米新一 (2013.8)
出生後の黒毛和種新生子牛への免疫グロブリンGと免疫グロブリンAの
移行
日本畜産学会報
 84:389-393.


Kume S
(2013)
Evaluation of methane production in high producing cows fed silages during periparturient period.
Advances in Animal Biosciences 4:306.

久米新一 (2013)
子牛の栄養・代謝の特異性
家畜感染症学会誌 2:51-56.


Murai I, Shukuin S, Sugimoto M, Ikeda S, Kume S (2013.6)
Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice.
Anim.Sci.J.
84:502-507.

Kuroki T
, Ikeda S, Okada T, Maoka T, Kitamura A, Sugimoto M, Kume S (2013.5)
Astaxanthin ameliorates heat stress-induced impairment of blastocyst development in vitro: -Astaxanthin colocalization with and action on mitochondria-.

J.Assist.Reprod.Genet.
30:623-631.

Wang M, Sugimoto M, Ikeda S, Kume S (2013.4)

Effects of coumestrol administration to maternal mice during pregnancy and lactation on IgA-secreting cells in mammary gland.

Anim.Sci.J.
84:322-327.

2018
Sugimoto M,
Kuwano A, Ikeda S, Kume S, Yoshihara E, Wada S (2012.11)
Investigation of hydration processes of the equine hoof via nuclear magnetic resonance microscopy.
Am.J.Vet.Res. 73: 1775-1780.

Yasumatsuya K, Kasai K, Yamanaka K, Sakase M, Nishino O, Akaike M, Mandokoro K, Nagase T, Kume S (2012.2)
Effects of feeding whey protein on growth rate and mucosal IgA induction in Japanese black calves.
Livestock Science 143:210-213.


Koyama H, Ikeda S, Sugimoto M, Kume S (2012.12)

Effects of folic acid on the development and oxidative stress of mouse embryos exposed to heat stress.
Reprod.Domest.Anim. 47:921-927.

Ikeda S, Koyama H, Sugimoto M, Kume S
(2012.2)
Review: Roles of one-carbon metabolism in preimplantation period−Effects on short-term development and long-term programming−
J.Reprod.Dev. 58:38-43.

Ikeda S, Sugimoto M, Kume S
(2012.2)
Importance of methionine metabolism in morula-to-blastocyst transition in bovine preimplantation embryos.
J.Reprod.Dev. 58:91-97.


Ueda M, Horiguchi Y, Sugimoto M, Ikeda S, Kume S
(2012.6)
Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice.
Anim.Sci.J. 83:469-473.

Otsuka H, Sugimoto M, Ikeda S, Kume S
(2012.3)
Effects of bisphenol A administration to pregnant mice on serum Ca and intestinal Ca absorption.
Anim.Sci.J. 83:232-237.

Sai T, Matsuda F, Goto Y, Maeda A, Sugimoto M, Gao HM, Kabir AK, Li JY, Manabe N (2012.2)
Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells.
J.Reprod.Dev. 58:112-116.


2018
Kirihata Y, Horiguchi Y, Ueda M, Sugimoto M, Ikeda S, Kume S
(2011.5)
Effects of coumestrol administration to pregnant and lactating mice on intestinal alkaline phosphatase activity.
Phytotherapy Research 25:654-658.


安松谷恵子・笠井浩司・濱野貴史・西野治・赤池勝・林道也・久米新一・永瀬辰男 (2011.2)
人工ほ乳における代用乳の給与量の変更が黒毛和種子牛の発育とスタータ摂取量に及ぼす影響
関西畜産学会報 168:17-23.


Kume S, Sato T, Murai I,
Kitagawa M, Nonaka K, Oshita T (2011.6)
Relationships between urine pH and electrolyte status in cows fed forages.
Anim.Sci.J. 82:456-460.


Nishiyama Y,
Yasumatsuya K, Kasai K, Sakase M, Nishino O, Akaike M, Nagase T, Sugimoto M, Ikeda S, Kume S (2011.5)
Effects of supplemental β-carotene with whey on IgA transfer from maternal milk and mucosal IgA induction in neonatal mice and calves.
Livestock Science 137:95-100.


Nishiyama Y, Sugimoto M, Ikeda S, Kume S
(2011.1)
Supplemental β-carotene increases IgA secreting cells in mammary gland and IgA transfer from milk to neonatal mice.
British Journal of Nutrition
105:24-30.

Sai T, Goto Y, Yoshioka R, Maeda A, Matsuda F, Sugimoto M, Wongpanit K, Jin HZ, Li JY, Manabe N (2011.6)
Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries.
J.Reprod.Dev. 57:421-427.


2018
Sugimoto M, Kagawa N, Morita M, Kume S, Wongpanit K, Jin H, Manabe N (2010.8)
Changes in the expression of decoy receptor 3 in granulosa cells during follicular atresia in porcine ovaries.
J.Reprod.Dev. 56:467-474.


高木菜穂子長谷川清香池田俊太郎杉本実紀久米新一 (2010.2)
離乳後のマウスの窒素利用効率および糞中IgAに及ぼすホエータンパク質あるいは脱脂乳タンパク質給与の影響
関西畜産学会報 166:1-9.

笠井浩司・安松谷恵子・瀬山智博・平康博章・藤谷泰裕・万所幸喜・赤池勝・西野治・久米新一 (2010.2)
妊娠乳牛への下痢5種混合ワクチンの接種が分娩後の初乳中の免疫グロブリンG濃度および抗体価に及ぼす影響

関西畜産学会報 166:27-32.

Namekawa T, Ikeda S, Sugimoto M, Kume S (2010.12)
Effects of astaxanthin-containing oil on development and stress-related gene expression of bovine embryos exposed to heat stress.

Reprod.Domest.Anim. 45:e387-e391.

Ikeda S, Namekawa T, Sugimoto M, Kume S (2010.3)
Expression of methylation pathway enzymes in bovine oocytes and preimplantation embryos.
J.Exp.Zool.A.Ecol.Genet.Physiol. 313:129-136.

Kume S, Nonaka T, Oshita T, Kozakai T (2010.3)
Evaluation of drinking water intake, feed water intake and total water intake in dry and lactating cows fed silages.
Livestock Science 128:46-51.


Murai I, Sugimoto M, Ikeda S, Kume S (2010.2)
Effects of high potassium chloride supplementation on water intake, urine volume and nitrogen balance in mice.

Anim.Sci.J.
81:80-84.

Ikeda S, Sugimoto M, Kume S (2010.4)
Dynamic expression of vimentin in bovine blastocysts in extended in vitro culture.
Reprod.Domest.Anim. 45:295-301.


2018
Tabata Y, Togo D, Kitagawa M, Oishi K, Kumagai H, Kume S, Hirooka Y (2009.8)
Nitrogen, phosphorus, and potassium utilization and their cycling in a beef-forage production system.
Anim.Sci.J. 80:475-485.


Asakura M, Ninomiya S, Sugimoto M, Oku M, Yamashita SI, Okuno T, Sakai Y, Takano Y (2009.4)
Atg26-mediated pexophagy is required for host invasion by the plant pathogenic fungus Colletotrichum orbiculare.

Plant Cell 21:1291-1304.

Ikeda S, Tatemizo A, Iwamoto D, Taniguchi S, Hoshino Y, Amano T, Matsumoto K, Hosoi Y, Iritani A, Saeki K (2009.8)
Enhancement of histone acetylation by trichostatin A during in vitro fertilization of bovine oocytes affects cell number of inner cell mass of the resulting blastocysts.
Zygote 17: 209-215.


2018
西岡輝美・石塚譲・安松谷恵子・久米新一・入江正和 (2008.11)
市場における黒毛和牛の枝肉単価に及ぼす格付項目および脂肪
の理化学的特性の影響
日本畜産学会報 79:515-525.

Kume S, Numata K, Takeya Y, Miyagawa Y, Ikeda S, Kitagawa M, Nonaka K, Oshita T, Kozakai T (2008.8)
Evaluation of urinary nitrogen excretion from plasma urea nitrogen in dry and lactating cows.
Asian-Aust.J.Anim.Sci. 21:1159-1163.


Kume S, Nonaka K, Oshita T, Kozakai T, Hirooka H (2008.5)

Effects of urinary excretion of nitrogen, potassium and sodium on urine volume in dairy cows.

Livestock Science 115:28-33
.


Kirihata Y, Kawarabayashi T, Imanishi S, Sugimoto M, Kume S (2008.2)
Coumestrol decreases intestinal alkaline phosphatase activity in post-delivery mice but does not affetct vitamin D receptor and calcium channels in post-delivery and neonatal mice.
J.Reprod.Dev. 54:35-41.


Murai I, Imanishi S, Sugimoto M, Kume S (2008.4)
Effects of high potassium chloride supplementation on growth rate and renal function in mice.
Anim.Sci.J. 79:243-247.


Oshita T, Sudo K, Nonaka K, Kume S, Ochiai K (2008.2)
The effect of feed regimen on chewing time, digesta passage rate and particle size distribution in Holstein non-lactating cows fed pasture ad libitum.
Livestock Science 113:243-250.


2018

Imanishi S, Sugimoto M, Morita M, Kume S, Manabe N (2007.10)
Changes in expression and localization of GPRC5B and RARα in the placenta and yolk sac during middle to late gestation in mice.
J.Reprod.Dev. 53:1131-1136.

Padilla L, Matsui T, Ikeda S, Kitagawa M, Yano H (2007.12)
The effect of vitamin C supplementation on plasma concentration and urinary excretion of vitamin C in cattle.
J.Anim.Sci. 85:3367-3370.

Rodriguez A, Diez C, Caamano JN, de Frutos C, Royo LJ, Munoz M, Ikeda S, Facal N, Alvarez-Viejo M, Gomez E (2007.11)
Retinoid receptor-specific agonists regulate bovine in vitro early embryonic development, differentiation and expression of genes related to cell cycle arrest and apoptosis.
Theriogenology 68:1118-1127
.

Goel S, Sugimoto M, Minami N, Yamada M, Kume S, Imai H (2007.7)
Identification, isolation, and in vitro culture of porcine gonocytes.
Biol.Reprod. 77:123-137.

Oshita T, Takayama H, Otsuka S, Igarashi H, Nonaka K, Kume S (2007.4)
Effects of maturing stage of corn hybrids on silage yield, feeding value for dairy cows and milk production in a cold region of Japan.
Asian-Aust.J.Anim.Sci. 20:511-516.


2018
久米新一・長野京子・木村一雅 (2006)
子牛の健康状態・ミネラル代謝におよぼすガラクトオリゴ糖給与の影響.
微量栄養素研究 23:22-27.

久米新一 (2006)
ウシのメタン発生量と窒素およびミネラル排泄量の制御.
畜産システム研究会報 30:25-33.

Chan MP, Morisawa S, Nakayama A, Kawamoto Y, Sugimoto M, Yoneda M (2006)
A physiologically based pharmacokinetic model for endosulfan in the male Sprague-Dawley rats.
Environmental Toxicology 21:464-478.

Ikeda S, Saeki K, Imai H, Yamada M (2006)
Abilities of cumulus and granulosa cells to enhance the developmental competence of bovine oocytes during in vitro maturation period are promoted by midkine; A possible implication of its apoptosis suppressing effects.
Reproduction 132:549-557.

Ikeda S, Prendes JM, Alonso-Montes C, Rodriguez A, Diez C, Kitagawa M, Imai H, Gomez E (2006)
Apoptosis-independent poor morphology of bovine embryos produced by multiple ovulation.
Reprod. Domest. Anim. 41:383-385.

Rodriguez A, Diez C, Ikeda S, Royo LJ, Caamano JN, Alonso-Montes C, Goyache F, Alvarez I, Facal N, Gomez E (2006)
Retinoids during the in vitro transition from bovine morula to blastocyst.
Hum. Reprod. 21:2149-2157.

Gomez E, Diez C, Caamano JN, Goyache F, Royo LJ, Rodriguez A, de Frutos C, Facal N, Ikeda S (2006)
Nuclear receptors, small molecules and reproductive biothechnology.
A
ETE Newsletter
25:11-13.


2018
久米新一(2005)
高泌乳牛の繁殖成績改善と栄養管理(1).
家畜人工授精 226:24-39.

久米新一(2005)
高泌乳牛の繁殖成績改善と栄養管理(2).
家畜人工授精 227:40-55.

Kume S, Nonaka K, Oshita T, Kozakai T, Kojima K (2005)
Feeding alfalfa silage on methane production in dry and lactating cows.
Proc. 2nd Greenhouse Gases and Animal Agriculture 428-431.

Kojima H, Kume S, Nonaka K, Oshita T, Kozakai T, Hirooka H (2005)
Effects of feeding and animal performance on nitrogen, phosphorus and potassium excretion by Holstein cows.
Animal Science Journal 76:139-145.

Chan MP, Morisawa S, Nakayama A, Kawamoto Y, Sugimoto M, Yoneda M (2005)
Toxicokinetics of (14)C-endosulfan in male Sprague-Dawley rats following oral administration of single or repeated doses.
Environmental Toxicology 20:533-541.


Nishizawa H, Morita M, Sugimoto M, Imanishi S, Manabe N (2005)
Effects of in utero exposure to bisphenol A on mRNA expression of arylhydrocarbon and retinoid receptors in murine embryos.
J.Reprod.Dev. 51:315-324.

Morita J, Terada Y, Hosoi Y, Fujinami N, Sugimoto M, Nakamura S-I, Murakami T, Yaegashi N, Okamura K (2005)
Microtubule organization during rabbit fertilization by intracytoplasmic sperm injection with and without sperm centrosome.
Reproductive Medicine and Biology 4:169-177.

Uchio-Yamada K, Manabe N, Goto Y, Anann S, Yamamoto Y, Takano K, Ogura A, Matsuda J (2005)
Decreased expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in the kidneys of hereditary nephrotic (ICGN) mice.
J.Vet.Med.Sci. 67:35-41.

Kagawa N, Sakurai Y, Miyano T, Manabe N (2005)
Effects of long-term grafting on follicular growth in porcine ovarian cortical grafts xenoplanted to severe combined immunodeficient (SCID) mice.
J.Reprod.Dev. 51:77-85.

Kawamoto Y, Matsuyama W, Morikawa M, Morita M, Sugimoto M, Manabe N, Morisawa S (2005)

Disposition of bisphenol A in pregnant mice and fetuses after a single and repeated oral administration.

Toxicol.Environ.Chem. 87:199-213.

Hidalgo C, Diez C, Duque P, Prendes JM, Rodriguez A, Goyache F, Fernandez I, Facal N, Ikeda S, Alonso-Montes C, Gomez E (2005)
Oocytes recovered from cows treated with retinol become unviable as blastocysts produced in vitro.
Reproduction 129:411-421.

Ikeda S, Kitagawa M, Imai H, Yamada M (2005)
The roles of vitamin A in cytoplasmic maturation of bovine oocytes.
J
.Reprod.Dev.
51:23-35.


2018
久米新一・野中和久・大下友子・小酒井貴晴・小島英紀 (2004)
自給粗飼料多給時における乾乳牛、妊娠牛および泌乳牛のカリウム排泄量.
日本畜産学会報 75:179-184.

Oshita T, Nonaka K, Kume S, Nakui T (2004)
Effects of forage type on particle size distribution of ruminal digesta and faeces of non-lactating cows fed high quality forage.
Livestock Production Science 91:107-115.


久米新一・野中和久・大下友子・山口直己 (2004)
自給粗飼料多給時における乾乳牛の維持に要する代謝エネルギー要求量の推定.
日本畜産学会報 75:31-35.

Kume S, Toharmat T, Ridla M, Nonaka K, Oshita T, Nakamura M, Yamada Y, Ternouth JH (2004)
Effect of high potassium intake from alfalfa silage on mineral status in sheep and periparturient cows.
Res.Bull.Natl.Agric.Res.Cent.for Hokkaido Reg. 181:1-14.

Goto Y, Manabe N, Uchio K, Yamaguchi-Yamada M, Inoue N, Yamamoto Y, Ogura A, Nagano N and Miyamoto H (2004)
Myofibroblastic differentiation in tubulointerstitial cells is provoked by augmented cytoplasmic Smad4 protein in hereditary nephrotic ICGN mice with chronic renal fibrosis.
Cell Tissue Res. 315:209-221.

Uchio-Yamada K, Manabe N, Yamaguchi-Yamada M, Goto Y, Yamamoto Y, Ogura A, Miyamoto H (2004)
Changes in the localization of type I, III and IV collagen mRNAs in the kidneys of hereditary nephritic (ICGN) mice with renal fibrosis.
J.Vet.Med.Sci. 66:123-128.

Yamaguchi-Yamada M, Manabe N, Uchio-Yamada K, Akashi N, Goto Y, Miyamoto Y, Nagao M, Yamamoto Y, Ogura A, Miyamoto H (2004)
Anemia with chronic renal disorder and disrupted metabolism of erythropoietin in ICR-derived glomerulonephritis (ICGN) mice.
J.Vet.Med.Sci. 66:423-431.

Wollenhaupt K, Welter H, Einspanier R, Manabe N, Brussow KP (2004)
Expression of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation.
J.Reprod.Dev. 50:269-278.

Yamaguchi-Yamada M, Manabe N, Goto Y, Anan S, Miyamoto K, Miyamoto Y, Nagao M, Yamamoto Y, Ogura A (2004)
Improvement of anemia associated with chronic renal failure by recombinant human erythropoietin treatment in ICR-derived glomerulonephritis (ICGN) mice.
J.Vet.Med.Sci. 66:883-886.

Goto Y, Matsuda-Minehata F, Inoue N, Matsui T, Maeda A, Manabe N (2004)
Porcine (Sus scrofa) cellular FLICE-like inhibitory protein (cFLIP): Molecular cloning and comparison with the human and murine cFLIP.
J.Reprod.Dev. 50:549-555.


2018
Kume S, Nonaka K, Oshita T (2003)
Relationship between parity and mineral status in dairy cows during the periparturient period.
Animal Science Journal 74:211-215.


小島英紀・広岡博之・石田定顕・久米新一・島田和宏・林孝 (2003)
乳牛におけるリン排泄量予測モデルの開発とシミュレーション.
日本畜産学会報 73:499-507.

Santoso B, Kume S, Nonaka K, Kimura K, Mizukoshi H, Gamo Y, Takahashi J (2003)
Methane emission, nutrient digestibility, energy metabolism and blood metabolites in dairy cows fed silage with and without galacto-oligosaccharides supplementation.
Asian-Aust.J.Anim.Sci. 16:534-540.

Santoso B, Kume S, Nonaka K, Gamo Y, Kimura K, Takahashi J (2003)
Influence of β1-4 galacto-oligosaccharides supplementation on nitrogen utilization, rumen fermentation, and microbial nitrogen supply in dairy cows fed silage.
Asian-Aust.J.Anim.Sci. 16:1137-1142.


久米新一 (2003) 
乳牛の繁殖機能の改善と栄養管理.
日本胚移植学雑誌 25:29-37.

久米新一・野中和久・大下友子 (2003) 
乾乳牛のメタン発生量並びに窒素ミネラル排泄量に及ぼす給与粗飼料の影響.
北海道農研研報
178:21-34.

Komatsu K, Manabe N, Kiso M, Shimabe M, Miyamoto H (2003)
Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries.
J.Exp.Zool. 296:152-159.

Komatsu K, Manabe N, Kiso M, Shimabe M, Miyamoto H (2003)
Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries.
Mol.Reprod.Dev. 65:345-352.

Matsui T, Manabe N, Goto Y, Inoue N, Nishihara S, Miyamoto H (2003)
Changes in the expression and activity of caspase-9 and Apaf1 in granulosa cells during follicular atresia in pig ovaries.
Reproduction 126:113-120.

Egerszegi I, Schneider F, R_tky J, So_s F, Solti L, Manabe N, Br_ssow KP (2003)
Comparison of luteinizing hormone and steroid hormone secretion during the peri- and post-ovulatory periods in mangalica and landrace gilts.
J.Reprod.Dev. 49:291-296.

Inoue N, Manabe N, Matsui T, Maeda A, Nakagawa S, Wada S, Miyamoto H (2003)
Roles of tumor necrosis factor-related apoptosis-inducing ligand signaling pathway in granulosa cell apoptosis during atresia in pig ovaries.
J.Reprod.Dev. 49:313-321.

Imanishi S, Manabe N, Nishizawa H, Morita M, Sugimoto M, Iwahori M, Miyamoto H (2003)
Effects of oral exposure of bisphenol A on mRNA expression of nuclear receptors in murine placentae assessed by DNA microarray.
J.Reprod.Dev. 49:329-336.

Izumi T, Sakakida S, Nagai T, Miyamoto H (2003)
Allometric study on the relation between the growth of preantral and antral follicles and that of oocytes in bovine ovaries.
J.Reprod.Dev. 49:361-368.


榊田星史、泉徳和、松本夕佳、大西基子、西川知子、宮本元 (2003)
ウシ卵巣から600μm 未満の卵胞と卵母細胞対の分離方法が回収率に及ぼす影響
日本胚移植学雑誌 25:113-120.

Kiso M, Manabe M, Komatsu K, Shimabe M, Miyamoto H (2003)
Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM): expression of Fas Ligand/Fas-mediated apoptosis signaling molecules in luteal cells.
J.Reprod.Dev. 49:457-463.

Nishizawa H, Manabe N, Morita M, Sugimoto M, Miyamoto H (2003)
Effects of in utero exposure of bisphenol A on expression of RXRα and RARα mRNAs in murine embryos.
J.Reprod.Dev. 49:539-45.


杉本実紀、眞鍋昇、宮本元 (2003)
卵巣組織の凍結保存
医学のあゆみ 204: 921-925.

Ikeda S, Imai H, Yamada M (2003)
Apoptosis in cumulus cells during in vitro maturation of bovine cumulus-enclosed oocytes.
Reproduction 125:369-376.


2018
大下友子・野中和久・久米新一・岩渕 慶・我有 満 (2002)
ガレガサイレージの飼料成分組成、発酵品質および栄養価.
日本草地学会誌 48:428-432.

中村正斗・佐藤義和・矢用健一・山田 豊・坂口 実・久米新一 (2002)
分娩前からのアルファルファサイレージの給与が乳熱発生、採食量および乳生産に及ぼす影響.
北海道畜産学会報 44:29-37.

Kume S (2002)
Establishment of profitable dairy farming system on control of methane production in Hokkaido region.
Greenhouse Gases and Animal Agriculture. 87-94. Elsevier Science Ltd.

Wada S, Manabe N, Inoue N, Nakayama M, Matsui T, Miyamoto H (2002)
TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries.
J.Reprod.Dev. 48:167-173.

Wada S, Manabe N, Inoue N, Nakayama M, Matsui T, Miyamoto H (2002)
TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries.
J.Reprod.Dev. 48:175-181.

Sugimoto M, Manabe N, Morita M, Tanaka T, Okamoto R, Imanishi S, Miyamoto H (2002)
Availability of NMR microscopic observation of mouse embryo disorder: Examination in malformations induced by maternal administration of retinoic acid.
J.Vet.Med.Sci. 64:427-433.

Wada S, Manabe N, Nakayama M, Inoue N, Matsui T, Miyamoto H (2002)
TRAIL-decoy receptor 1 plays inhibitory role in apoptosis of granulosa cells from pig ovarian follicles.
J.Vet.Med.Sci. 64:435-439.

Uchio K, Tuchweber B, Manabe N, Gabbiani G, Rosenbaum J, Desmouliere A (2002)
Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts.
Lab.Invest. 82:619-628.


2018
Kume S, Toharmat T (2001)
Effect of colostral β-carotene and vitamin A on vitamin and health status of newborn calves.
Livestock Production Science 68:61-65.

Kume S, Toharmat T, Nonaka K, Oshita T, Nakui T, Ternouth JH (2001)

Relationships between crude protein and mineral concentrations in alfalfa and value of alfalfa silage as a mineral source for periparturient cows.

Animal Feed Science and Technology 93:157-168.

Kume S, Toharmat T (2001)
Electrolyte status and fecal consistency in newborn calves.
Asian-Aust.J.Anim.Sci. 14:640-645.


野中和久・久米新一・大下友子 (2001)
摩砕処理が低水分サイレージのin sacco消化率並びに消化性に及ぼす影響.
日本草地学会誌 47:405-411.

久米新一・名久井忠・野中和久・大下友子 (2001)
アルファルファの生育による栄養価の変動.
北農
68:8-14.

Kume S, Okamoto T, Sasaki O, Uetake K, Yayou K, Ternouth JH (2001)
Effect of calving season and parity on milk yield and milk composition of high producing cows in Hokkaido.
Res.Bull.Hokkaido.Natl.Agric.Exp.Stn. 173:37-45.

Uchio-Yamada K, Manabe N, Yamaguchi M, Akashi N, Goto Y, Yamamoto Y, Ogura A, Miyamoto H (2001)
Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome.
J.Vet.Med.Sci. 63:1171-1178.

Yamaguchi M, Manabe N, Uchio-Yamada K, Akashi N, Yamamo Y, Ogura A, Miyamoto H (2001)
Localization of proliferative and apoptotic cells in the kidneys of ICR-derived glomerulonephritis (ICGN) mice.
J.Vet.Med.Sci. 63:781-787.

Manabe N, Kinoshita A, Yamaguchi M, Furuya Y, Nagano N, Yamada-Uchio K, Akashi N, Miyamoto-Kuramitsu K, Miyamoto, H (2001)
Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy.
J.Vet.Med.Sci. 63:125-133.